Project 1: Pharmacy enhanced services for people with type 2 diabetes
This project provided a digital platform for education and behaviour change for people living with type 2 diabetes.
Changing Health is a digital health service spin-out from Newcastle University. It delivered the national digital behaviour change platform. It also delivered the national type 2 diabetes digital education and behaviour change service. Both were for NHS England.
It is one of five providers for the national diabetes prevention programme. They delivered education and behaviour change to 200,000 people in England.
They provided digital education and behaviour change to 20 English clinical commissioning groups.
The service has licensed evidence-based programmes from other academic groups. These groups had previously found it difficult to commercialise digital behaviour change programmes.
Project 2: Mechanistic evaluation of stroke and mitochondrial dysfunction: toward clinically relevant therapies
This project aimed to test a range of parameters, including:
- demographic
- anthropomorphic
- physiological
- clinical
All testing occurred in a genetically defined group of patients with mitochondrial disease.
The project determined the patients' contribution to disease mechanisms. It also assessed their potential as clinical biomarkers and for clinical trials.
The project identified many clinical biomarkers and outcome measures. This data contributed to the largest clinical trial of a medicinal product in mitochondrial disease.
Project 3: Development of a non-invasive MRI method to image and quantify lung ventilation properties
This project investigated whether 19F-MRI of inhaled perfluoropropane could produce images of tracer distribution within the lung. It then explored if this data could provide reproducible metrics of lung ventilation properties.
Using this technique, we produced the first UK images of pulmonary ventilation properties. It demonstrated high reproducibility in a study of 12 healthy volunteers.
The project received MRC DPFS funding for scale-up of the methodology and next stage of human evaluation. The DPFS award has delivered robust scan methodology. We applied this in two-site UK studies of healthy volunteers and patients with respiratory.
The next steps of the translational pathway are being planned. This will test the ability to inform clinical decision-making. It will also implement the methods into clinical care pathways.
